A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4458 (2006.01) A61K 9/127 (2006.01) A61K 31/167 (2006.01)
Patent
CA 2340118
Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising "GMV" (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
On décrit des compositions de liposomes de bupivacaine préparées par un procédé de charge par gradient de sulfate d'ammoniumn, à un pH pouvant empêcher que le médicament ne soit précipité de la solution de charge. On décrit également des suspensions de liposomes contenant des liposomes'GMV' (multivésiculaires géants), et des procédés de préparation desdits liposomes. Ces compositions de liposomes se caractérisent par des rapports médicament-lipide élevés et prosuisent un effet analgésique durable.
Barenholz Yechezkel
Bolotin Elijah M.
Grant Gilbert J.
Piskoun Boris
Turndorf Herman
Gowling Lafleur Henderson Llp
New York University
Yissum Research Development Company Of The Hebrew University Of
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