Liposomal camptothecin formulations

Details Liposomal camptothecin formulations Liposomal camptothecin formulations

A - Human Necessities

61

K

A61K 31/495 (2006.01) A61K 9/127 (2006.01) A61K 31/4745 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2303366

Liposomal encapsulated camptothecin formulations are provided. The liposomes have improved pharmacokinetics, enhanced efficacy as anti-tumor agents and provide an increased therapeutic index as compared to the free drug and topotecan. The formulations include liposomes comprising at least one phospholipid and a camptothecin or analog thereof.

L'invention se rapporte à des compositions encapsulées à base de liposomes qui renfermant de la camptothécine. Les liposomes présentent des propriétés pharmacocinétiques et une efficacité améliorée en tant qu'agents anti-tumoraux et fournissent un indice thérapeutique accru par rapport à celui d'un médicament libre et du topotécan. Ces compositions renferment des liposomes contenant au moins un phospholipide et une campothécine ou un analogue de cette dernière.

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