Liposomal composition comprising water-soluble...

Details Liposomal composition comprising water-soluble... Liposomal composition comprising water-soluble...

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 31/573 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2430897

A pharmaceutical composition for parenteral administration, comprising liposomes composed of non-charged vesicle-forming lipids, including up to 20 mole percent of an amphipathic vesicle-forming lipid derivatised with polyethyleneglycol, and optionally including not more than 10 mole percent of negatively charged vesicle-forming lipids, the liposomes having a selected mean particle diameter in the size range between about 40-200 nm and containing a water soluble corticosteroid for the site-specific treatment of inflammatory disorders, is provided.

L'invention porte sur une composition pharmaceutique destinée à être administrée par voie parentérale et comprenant des liposomes constitués de lipides non chargés formant des vésicules, et comprenant jusqu'à 20 % en mole d'un lipide amphipathique formant des vésicules et dérivatisé par le polyéthylèneglycol. Cette composition comprend éventuellement 10 % maximum en mole de lipides chargés négativement formant des vésicules, les liposomes ayant un diamètre moyen sélectionné de particule compris entre environ 40 et 200 nm et contenant un corticostéroïde soluble dans l'eau destiné à être utilisé dans le traitement de maladies inflammatoires.

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