Liposomal compositions for parenteral delivery of agents

Details Liposomal compositions for parenteral delivery of agents Liposomal compositions for parenteral delivery of agents

A - Human Necessities

61

K

A61K 31/4174 (2006.01) A61K 9/127 (2006.01) A61K 47/48 (2006.01) A61P 31/10 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2596131

The invention provides methods and compositions for loading an agent, such as econazole, onto a liposome for parental delivery. The loading of the agent into a liposome comprises combining the agent with a micelle-forming compound to form a micelle including the agent, where the agent is releasable from the micelle-forming compound, and adding the micelle to the liposome, where the micelle combines with the liposome such that the agent is loaded into the liposome to form a loaded liposome. The methods are suitable for the loading of poorly soluble agents onto liposome.

La présente invention se rapporte à des méthodes et à des compositions permettant d'incorporer un agent, tel que de l'éconazole, dans un liposome, aux fins d'administration parentérale. L'incorporation dudit agent dans un liposome consiste à combiner l'agent avec un composé formant une micelle, afin de former une micelle contenant l'agent, ce dernier pouvant être libéré du composé formant une micelle, et à ajouter la micelle au liposome, ladite micelle se combinant à ce dernier de façon que l'agent soit incorporé dans le liposome afin de former un liposome chargés. Les procédés selon l'invention conviennent à l'incorporation d'agents peu solubles dans un liposome.

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