Liposomal delivery of vitamin e based compounds

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/127 (2006.01) A61K 9/50 (2006.01) A61K 9/51 (2006.01) A61K 31/355 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2470920

The present invention provides a method for treating a cell proliferative disease by delivering a composition comprising a vitamin E based anti-cancer compound contained within a delivery vesicle of an individual in need of such treatment where the compound has a structural formula where R' is a hydrogen or a carboxylic acid; R2 and R3 are hydrogen or R4; R4 is methyl; and R5 is alkyl. Also provided is a vesicle comprising these compounds.

La présente invention se rapporte à un procédé de traitement d'une maladie associée à une prolifération cellulaire par administration à un sujet justiciable d'un tel traitement d'une composition comportant un composé anticancéreux à base de vitamine E contenu dans une vésicule d'administration. Ledit composé présente la formule structurelle représentée par la formule (I), dans laquelle R?1¿ est un atome d'hydrogène ou un acide carboxylique; R?2¿ et R?3¿ sont hydrogène ou R?4¿; R?4¿ est méthyle; et R?5¿ est alkyle. L'invention se rapporte également à une vésicule contenant ces composés.

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