Liposomal formulation for oral administration of glutathione...

A - Human Necessities – 61 – K

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A61K 9/127 (2006.01)

Patent

CA 2628777

The invention is a composition administrable orally to provide systemic glutathione (reduced) and a method for providing systemic glutathione by oral administration of glutathione (reduced) in a liposome encapsulation. The administration of a therapeutically effective amount of oral liposomal glutathione (reduced) results in improvement of symptoms in disease states related to glutathione deficiency such as Parkinson's disease and cystic fibrosis. Compounds enhancing the effect of the liposomal glutathione are contemplated such as Selenium, EDTA, carbidopa, and levodopa.

La présente invention concerne une composition pouvant être administrée par voie orale pour produire du glutathione (réduit) systémique et un procédé permettant de produire du glutathione systémique par administration par voie orale de glutathione (réduit) par une encapsulation dans des liposomes. L'administration d'une quantité thérapeutiquement efficace de glutathione (réduit) liposomal par voie orale entraîne une amélioration des symptômes dans des états pathologiques associés à une carence en glutathione tels que la maladie de Parkinson et la fibrose kystique. Cette invention concerne également des composés renforçant l'effet du glutathione liposomal, tels que le sélénium, l'EDTA, la carbidopa et la lévodopa.

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