A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 9/133 (2006.01) A61K 31/136 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2424345
This invention pertains to liposomal formulations of mitoxantroneand methods for their manufacture and use. The compositions of the present invention include liposomal formulations of mitoxantrone in which the liposome contains any of a variety of neutral or charged liposome-forming materials in addition to a compound that is thought to bind mitoxantrone, such as cardiolipin. The liposomal compositions can be used advantageously in conjunction with secondary therapeutic agents other than mitoxantrone, including antineoplastic, antifungal, antibiotic among other active agents. Methods are provided in which a therapeutically effective amount of the formulation is administered to a mammal, such as a human.
Cette invention concerne des préparations liposomales à base de mitoxantrone et des méthodes de production et d'utilisation de ces préparations. Les compositions de l'invention comprennent des préparations liposomales à base de mitoxantrone dans lesquelles le liposome contient l'une quelconque d'une gamme de matières de formation de liposome neutres ou chargées en plus d'un composé réputé se lier à la mitoxantrone, tel que la cardiolipine. Les compositions liposomales de l'invention peuvent être utilisées avantageusement en combinaison avec des agents thérapeutiques secondaires autres que la mitoxantrone, y compris des agents antinéoplastiques, antifongiques, antibiotiques, entre autres agents actifs. L'invention concerne en outre des méthodes grâce auxquelles une quantité thérapeutiquement effective de la préparation est administrée à un mammifère, tel qu'un être humain.
Ahmad Imran
Rahman Aquilur
Neopharm Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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