Liposomal formulations of anthracycline agents and cytidine...

A - Human Necessities – 61 – K

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Details

A61K 31/7068 (2006.01) A61K 9/127 (2006.01) A61K 31/704 (2006.01) A61K 31/706 (2006.01)

Patent

CA 2564542

Compositions which comprise an anthracycline agent, and a cytidine analog are encapsulated in liposomal carriers. The preferred anthracycline agent is selected from the group of daunorubicin, doxorubicin, and idarubicin, while the preferred cytidine analog is selected from the group of cytarabine, gemcitabine, or 5-azacytidine. The combination of the anthracycline agent and cytidine analog encapsulated in said liposomal carriers are useful in achieving a drug retention and a sustained drug release for each therapeutic agent.

La présente invention concerne des compositions comprenant un anthracyclinique et un analogue cytidinique, encapsulés dans un vecteur intracellulaire de médicament. L'anthracyclinique est choisi dans le groupe de la daunorubicine, de la doxorubicine et de l'idarubicine, alors que l'analogue cytidinique préféré est choisi dans le groupe de la cytarabine, de la gemcitabine, ou de la 5-azacytidine. Cette combinaison ainsi encapsulée permet une rétention du médicament et une libération prolongée pour chaque agent thérapeutique.

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