Liposomal phosphodiester, phosphorothioate, and p-ethoxy...

Details Liposomal phosphodiester, phosphorothioate, and p-ethoxy... Liposomal phosphodiester, phosphorothioate, and p-ethoxy...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) A61K 47/06 (2006.01) A61K 47/24 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2228944

An improved delivery system for antisense oligonucleotides involves a liposomal composition, comprising a liposome which consists essentially of neutral phospholipids and an antisense oligonucleotide that is entrapped in the liposome and is selected from the group consisting of phosphodiester oligonucleotides, phosphorothioate oligonucleotides, and p-ethoxy oligonucleotides.

Ce système amélioré d'apport d'oligonucléotides anti-sens comporte une composition liposomale contenant un liposome, essentiellement constitué de phospholipides neutres, et un oligonucléotide anti-sens qui est piégé dans le liposome et est choisi dans le groupe constitué d'oligonucléotides phosphodiester, d'oligonucléotides phosphorothioate et d'oligonucléotides p-éthoxy.

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