Liposomal systems comprising sphingomyelin

Details Liposomal systems comprising sphingomyelin Liposomal systems comprising sphingomyelin

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 31/445 (2006.01)

Patent

CA 2739822

The present disclosure provides a liposomal system comprising an aqueous medium having dispersed therein liposomes encapsulating in their intraliposomal aqueous compartment at least one active agent, the aqueous medium being in iso-osmotic equilibrium with said intraliposomal aqueous compartment, the liposomes having a membrane comprising a liposome forming lipids, at least one of which being sphingomyelin (SPM), the liposomal system having increased stability as compared to the same liposomes free of SPM, and in one embodiment being stable during long- term storage, said stability being characterized in that no more than 30% of the at least one active agent is present in the aqueous medium after said storage. Further provided by the present disclosure are a method for storage of liposomes making use of the liposomal system; use of the liposomal system for the treatment of a medical condition or for the diagnostic of a medical condition; a pharmaceutical or diagnostic composition comprising the liposomal system, and a method of treating or diagnosing of a medical condition comprising administering to a subject an amount of the liposomal system.

La présente invention concerne un système liposomique comprenant un milieu aqueux dans lequel sont dispersés des liposomes encapsulant dans leur compartiment aqueux intraliposomique au moins un agent actif, le milieu aqueux étant en équilibre iso-osmotique avec ledit compartiment aqueux intraliposomique, les liposomes ayant une membrane comprenant des lipides formant des liposomes, dont au moins un est la sphingomyéline (SPM), le système liposomique ayant une stabilité augmentée par rapport aux mêmes liposomes exempts de SPM, et, dans un mode de réalisation, étant stable pendant la conservation à long terme, ladite stabilité étant caractérisée en ce que pas plus de 30 % de lau moins un agent actif est présent dans le milieu aqueux après ladite conservation. La présente invention concerne en outre un procédé pour la conservation de liposomes utilisant le système liposomique; lutilisation du système liposomique pour le traitement dune affection médicale; une composition pharmaceutique ou diagnostique comprenant le système liposomique, et un procédé de traitement ou de diagnostic dune affection médicale comprenant ladministration à un sujet du système liposomique.

Affiliated with

Also associated with

Rating

Liposomal systems comprising sphingomyelin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Liposomal systems comprising sphingomyelin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Liposomal systems comprising sphingomyelin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1460349