Liposomal-viral dna complexes for treating disease

A - Human Necessities – 61 – K

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Details

A61K 48/00 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2241142

Methods and compositions for treating cancer consisting of viral DNA in association with liposomal material, the viral DNA substantially incapable of encoding a functional viral oncoprotein capable of binding to a functional tumor suppressor gene product in a neoplastic cell, and the viral DNA capable of replicating and forming infectious virus in neoplastic cells thereby killing the neoplastic cells and substantially incapable or replicating and forming infectious virus in non-neoplastic cells that have the tumor suppressor protein.

L'invention concerne des compositions ainsi que les procédés correspondants, visant à traiter des cancers, ces compositions étant constituées d'un ADN viral associé à un liposome et l'ADN viral étant, dans une large mesure, dans l'incapacité de coder une onco-protéine virale fonctionnelle capable de se lier au produit d'un gène fonctionnel, suppresseur de tumeur, dans une cellule néoplasique. Cet ADN viral, qui est en mesure de se répliquer comme de produire un virus infectieux dans des cellules néoplasiques et, partant, de les tuer, est, par contre, quasiment dans l'incapacité de se répliquer comme de produire un virus infectieux dans des cellules non néoplasiques, porteuses de la protéine suppresseur de tumeur.

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