A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 48/00 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2468627
A liposome composition for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a lipid that is neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH and (ii) a lipid joined to a hydrophilic polymer by a dithiobenzyI linkage. The liposomes are associated with a nucleic acid for delivery to a cell.
L'invention concerne une composition de liposomes destinée à l'administration <i>in vivo</i> ou <i>ex vivo</i> d'un acide nucléique. Les liposomes de ladite composition contiennent (1) un lipide de charge neutre au pH physiologique, et de charge positive à un pH inférieur au pH physiologique, et (2) un lipide lié à un polymère hydrophile par une liaison dithiobenzyl. Lesdits liposomes sont associés à un acide nucléique destiné à être administré à une cellule.
Huang Shi-Kun
Zalipsky Samuel
Zhang Wei-Ming
Alza Corporation
Gowling Lafleur Henderson Llp
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