A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/00 (2006.01)
Patent
CA 2553426
A neutral cationic lipid and liposomes prepared from the neutral cationic lipid are described. Liposomes comprised of the lipid are suitable for delivery of a polyanionic compound, such as a nucleic acid. The delivery can be performed in vivo or ex vivo. The neutral cationic lipid, which is neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH, contains a polar head group that imparts solubility of the lipid and permits its packing into a liposomal lipid bilayer.
La présente invention a trait à un lipide cationique neutre et des liposomes préparés à partir du lipide cationique neutre. Des liposomes comportant le lipide sont appropriés pour l'administration d'un composé polyanionique, tel qu'un acide nucléique. L'administration peut être effectuée in vivo ou ex vivo. Le lipide cationique neutre, qui est neutre en charge à un pH physiologique et positivement chargé à des valeurs de pH inférieures au pH physiologique, contient un groupe de tête polaire qui procure une solubilité au lipide et permet son encapsulation dans une bicouche lipidique liposomale.
Huang Shi Kun
Zalipsky Samuel
Zhang Weiming
Alza Corporation
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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