A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01)
Patent
CA 2269758
A liposome composition containing encapsulated ionizable compound in the form of a co-precipitate with a charged precipitating agent including a polyionic polymer or in poly-ionic nonpolymer, or in the form of a pH-induced precipitate, and a method for producing the composition, are disclosed. The concentration of precipitated compound within the liposomes is greater in the interior as compared to the bulk medium, and the concentration of compound within the liposomes is not reduced in the presence of a proton or alkali metal-ion ionophore added to the bulk medium.
L'invention concerne une composition de liposome contenant un composé encapsulé dans une forme précipitée stable, ainsi qu'un procédé de production de cette composition. La concentration de composé précipité dans les liposomes est plusieurs fois supérieure à la concentration dans le milieu de support, et la concentration de composé dans les liposomes n'est pas réduite si un ionophore de transport de protons ou d'ions de métal alcalin est ajouté à la suspension.
Kirpotin Dmitri
Hermes Biosciences Inc.
Johnson Ernest Peter
LandOfFree
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