Liposome compositions for improved drug retention

Details Liposome compositions for improved drug retention Liposome compositions for improved drug retention

A - Human Necessities

61

K

A61K 31/496 (2006.01) A61K 9/127 (2006.01) A61K 31/5383 (2006.01) A61K 47/30 (2006.01) A61K 47/48 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2371483

A liposome composition for enhanced retention of a quinolone compound, and in particular of a fluoroquinolone compound, is described. Entrapped in the liposomes is a polyanionic polymer effective to form a complex with the fluoroquinolone. A method of preparing the liposomes which includes a process for removal of unentrapped polyanionic polymer is also described.

L'invention concerne une composition liposomique pour une rétention améliorée d'un composé de quinolone, et plus particulièrement d'un composé de fluoroquinolone. Un polymère polyanionique est piégé dans les liposomes de cette composition de manière à former un complexe avec la fluoroquinolone. Cette invention concerne également un procédé de préparation de ces liposomes, et notamment un processus permettant d'éliminer un polymère polyanionique non piégé.

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