Liposome drug carriers with ph-sensitivity

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/127 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2689624

A liposome composition for delivering of a biologically active agent having at a least first rigid lipid and a second rigid lipid each having a head group and a hydrophobic tail; a polyethyleneglycol-linked lipid having a side chain matching at least a portion of the first or the second lipid; and an entrapped biologically active agent. The first lipid can be a zwitterionic lipid and the second lipid can have a titratable head group. The composition can be adapted to release the entrapped at a certain pH.

L'invention concerne une composition liposomique pour délivrer un agent biologiquement actif, comprenant au moins un premier lipide rigide et un deuxième lipide rigide ayant chacun un groupe de tête et une queue hydrophobe ; un lipide lié à du polyéthylèneglycol ayant une chaîne latérale correspondant à au moins une portion du premier ou du deuxième lipide ; et un agent biologiquement actif piégé. Le premier lipide peut être un lipide zwitterionique et le deuxième lipide peut comprendre un groupe de tête titrable. La composition peut être conçue pour libérer le composé piégé à un certain pH

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