Liposome encapsulated amphiphilic drug compositions

Details Liposome encapsulated amphiphilic drug compositions Liposome encapsulated amphiphilic drug compositions

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 31/32 (2006.01) A61K 31/415 (2006.01) A61K 31/445 (2006.01) A61K 31/485 (2006.01) A61K 31/555 (2006.01) A61K 47/24 (2006.01) A61K 47/28 (2006.01)

Patent

CA 2250073

A process for the entrapment of amphiphilic compounds as uncharges on ionic mole ratios of phospholipid to the amphiphilic compound. Preparations of ionic species of amphiphilic compounds in the absence of crystals can be prepared, whilst preparations of uncharged amphiphilic compounds can be prepared with the compound exclusively entrapped inside the liposomes, or partly entrapped inside the liposomes with extraliposomal crystals.

L'invention a pour objet un procédé pour piéger les composés amphiphiles sous forme de rapports molaires ioniques de phospholipides sur le composé amphiphile. Des préparations d'espèces ioniques de composés amphiphiles, en l'absence de cristaux, peuvent être préparées, tandis que des préparations de composés amphiphiles non chargés peuvent être préparées avec le composé exclusivement enfermé à l'intérieur des liposomes, ou partiellement enfermés à l'intérieur des liposomes, avec des cristaux extraliposomiques.

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