Liposome-encapsulated poly iclc

Details Liposome-encapsulated poly iclc Liposome-encapsulated poly iclc

A - Human Necessities

61

K

A61K 31/713 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2203843

Although poly ICLC possess a broad spectrum of antimicrobial and anticancer activities, it therapeutic potential has yet to be fulfilled due to its toxic side effect. This problem can be overcome by encapsulating poly ICLC within liposomes which provides a drug delivery system with slow sustained release characteristic and which has the ability to target the drug to sites of infection and tumor without causing systemic burden to normal tissues, thereby enhancing the immunological and biological activities of poly ICLC.

Malgré la vaste gamme d'activités antimicrobiennes et anticancéreuses exercées par le poly ICLC, il reste à dégager son potentiel thérapeutique en raison de son effet secondaire toxique. Le problème peut être surmonté en encapsulant le poly ICLC dans des liposomes. On obtient alors un système d'administration de médicaments libérés lentement et de façon soutenue et qui peut cibler le médicament sur des sites d'infection et de tumeur sans imposer de charge systémique aux tissus normaux, améliorant ainsi les activités immunologiques et biologiques du poly ICLC.

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