A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 48/00 (2006.01) C12N 15/88 (2006.01) A61K 9/00 (2006.01)
Patent
CA 2386024
An oral vaccine comprises liposomes and complexed or, preferably, entrapped DNA operatively encoding an antigen, in which the liposomes are formed from components including cationic compounds and zwitterionic phospholipids. The hydrophobic groups within the liposome forming compounds must include at least one group which is saturated. This is believed to raise the transition temperature, rendering the liposomes more stable when delivered orally. The compositions have been found to give detectable increased in IgA levels, secreted immunoglobulins of importance in efficacious oral vaccine delivery.
L'invention concerne un vaccin oral contenant des liposomes et un ADN complexe ou, de préférence, piégé codant pour un antigène, dans lequel les liposomes sont formés à partir de composants comprenant des composés cationiques et des phospholipides zwittérioniques. Les groupes hydrophobiques des composés formant les liposomes comprennent au moins un groupe saturé, ce qui élève la température de transition, rendant les liposomes plus stables lorsqu'ils sont administrés par voie orale. Ces compositions génèrent une augmentation décelable des niveaux d'IgA, des immunoglobulines sécrétées très importantes dans l'administration orale efficace d'un vaccin.
Gregoriadis Gregory
Perrie Yvonne
Borden Ladner Gervais Llp
Lipoxen Technologies Limited
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