A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 9/127 (2006.01) A61K 31/7088 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2294579
A liposome composition for administration of a polynucleotide and a method of preparation of the composition are described. The liposomes in the suspension are composed predominantly of liposomes having a bilayer membrane formed of cationic vesicle-forming lipids and neutral vesicle-forming lipids. The polynucleotide is entrapped in the central core of the liposomes and is localized predominantly on the inner surface of the core.
Cette invention se rapporte à une composition de liposomes destinée à l'administration d'un polynucléotide et à un procédé de préparation de cette composition. Les liposomes de la suspension sont composés principalement de liposomes possédant une membrane bicouche formée de lipides cationiques susceptibles de former des vésicules et de lipides neutres susceptibles de former des vésicules. Le polynucléotide est piégé dans le noyau central des liposomes et se trouve principalement localisé sur la surface interne du noyau.
Allen Theresa M.
Stuart Darrin
Alza Corporation
Gowling Lafleur Henderson Llp
Sequus Pharmaceuticals Inc.
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