Liposome formulation of peptide boronic acids compounds

Details Liposome formulation of peptide boronic acids compounds Liposome formulation of peptide boronic acids compounds

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 47/10 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2586354

A liposome composition comprised of liposomes having a peptide boronic acid proteasome inhibitor compound entrapped in the liposome is described. The boronic acid compound is entrapped in the liposome in the form of a boronate ester, subsequent to interaction with a liposome-entrapped polyol. In one embodiment, the liposomes have an outer coating of hydrophilic polymer chains and are used to treat a malignancy in a subject.

La présente invention a trait à une composition liposomale comportant des liposomes présentant un composé inhibiteur du protéasome à base d'acide boronique peptidique piégé dans le liposome. Le composé à base d'acide boronique est piégé dans le liposome sous la forme d'un ester de boronate, conséquent à une interaction avec un polyol piégé dans des liposomes. Dans un mode de réalisation, les liposomes présentent un revêtement extérieur de chaînes polymères hydrophiles et sont utilisés pour le traitement de malignité chez un sujet.

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