Liposome-formulations for treatment of viral diseases

Details Liposome-formulations for treatment of viral diseases Liposome-formulations for treatment of viral diseases

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 31/4725 (2006.01) A61K 31/7056 (2006.01)

Patent

CA 2201631

A method is disclosed for the treatment of viral diseases comprising the administration of antiviral agents encapsulated in liposomes. Also provided are formulations of liposomes for the treatment of viral diseases and more particularly for the treatment of infectious caused by viruses like human immunodeficiency virus (HIV) and cytomegalovirus (CMV). These formulations of liposomes are composed of specific classes of lipid components and contain an entrapped drug effective against the viral disease. These liposomal formulations of antiviral drugs allow high cellular penetration in different cell lines, good in vitro antiviral efficacy against HIV and CMV replication, efficient in vivo targeting of HIV reservoirs and a marked improvement of the pharmacokinetics of drugs.

L'invention concerne un procédé de traitement des maladies virales, consistant à administrer des agents antiviraux encapsulés dans des liposomes. L'invention se rapporte en outre à des formulations liposomiques destinées au traitement de maladies virales, et plus particulièrement au traitement d'infections causées par des virus tels que le virus de l'immunodéficience humaine (VIH) et les cytomégalovirus (CMV). Elles sont composées de classes spécifiques de constituants lipidiques et contiennent un médicament encapsulé agissant efficacement contre la maladie virale. Ces formulations liposomiques contenant des médicaments antiviraux assurent une pénétration importante dans les cellules de différentes lignées cellulaires, présentent une bonne efficacité antivirale in vitro par rapport à la réplication du VIH et du CMV ainsi qu'un ciblage efficace in vivo des réservoirs de VIH, tout en améliorant considérablement la pharmacocinétique des médicaments.

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