Liposome preparation

Details Liposome preparation Liposome preparation

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2184834

A liposome preparation comprising a water-soluble 2'deoxy-2'- methylidenecytidine compound encapsulated therein and a compound which positively charges the surface of lipid membrane. This liposome preparation is not only expect d to decrease toxicity to myeloid tissue, which is caused by a water-soluble 2'-deoxycytidine compound having anti-malignant tumor activity, but also expected to accumulate the active ingredient in tumor tissues by virtue of an improved residence thereof in blood. Therefore, the preparation can maintain or enhance anti-tumor effects without causing side effects, and is useful for the treatment of malignant tumors.

Préparation de liposomes qui englobe un composé 2'-déoxycytidine soluble dans l'eau et qui charge positivement la surface d'une membrane lipidique. Etant donné que cette préparation doit avoir pour effet non seulement de réduire la toxicité du composé sus-mentionné pour les tissus médulaires présentant une résistance aux tumeurs malignes mais aussi de permettre l'accumulation de l'ingrédient actif dans le tissu tumoral grâce à une amélioration de la capacité de séjour dans le sang, elle préserve ou améliore l'effet antitumoral sans engendrer d'effets secondaires et se révèle utile pour le traitement des tumeurs malignes.

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