Liposome targeting of matrix metalloproteinase inhibitors

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/08 (2006.01) A61K 47/48 (2006.01) A61K 51/00 (2006.01) A61K 51/12 (2006.01)

Patent

CA 2441227

The present invention relates to targeted cancer therapy, and concerns specifically the use of small matrix metalloproteinase inhibitors in improving targeting of liposomes to cancer cells, and in enhancing the uptake thereof to such cells. The invention thus provides a method for treating cancer, as well as a method for improving targeting of liposomes to tumor cells, a method for enhancing the uptake of liposomes by tumor cells, and a method for selected liposomal delivery of chemotherapeutic agents into tumor cells.

La présente invention se rapporte à une thérapie anticancéreuse ciblée et concerne spéciquement l'utilisation de petits inhibiteurs des métalloprotéinases matricielles pour l'amélioration du ciblage de liposomes vers des cellules cancéreuses, et pour l'accroissement de l'apport de ces liposomes à de telles cellules. L'invention se rapporte également à une méthode de traitement du cancer, ainsi qu'à une méthode permettant d'améliorer le ciblage des liposomes vers des cellules tumorales, à une méthode d'accroissement de l'absorption des liposomes par les cellules tumorales ainsi qu'à une méthode d'administration liposomale sélectionnée d'agents chimiothérapeutiques dans les cellules tumorales.

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