Liposome treatment of viral infections

Details Liposome treatment of viral infections Liposome treatment of viral infections

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 31/445 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2659858

One can treat a viral infection such as hepatitis B (HBV), hepatitis C (HCV), and bovine viral diarrhea virus (BVDV) infections via the delivery of pH sensitive liposomes directly into the endoplasmic reticulum (ER) membrane. Two exemplary liposome formulations are DOPE/CHEMS (DC liposomes) and DOPE/CHEMS/PEG-PE (DCPP liposomes). DC and DCPP liposomes can optimize the intracellular delivery of N-butyl deoxynojirimycin (NB-DNJ), and consequently increase the in vivo activity of this iminosugar several orders of magnitude, and could be used in combination with other therapeutic agents such as interferon and/or ribavirin. The optimized release of NB-DNJ directly into the ER can be also applied for the treatment of other viruses, for which NB-DNJ is known to be an effective antiviral, such as human immunodeficiency virus (HIV).

Il est possible de traiter une infection virale du type hépatite B (HBV), hépatite C (HCV), et virus de la diarrhée virale bovine (BVDV) par l'apport de liposomes sensibles au pH directement dans la membrane du réticulum endoplasmique (ER). Deux formulations liposomales (exemples) sont DOPE/CHEMS ( liposomes DC) et DOPE/CHEMS/PEG-PE (liposomes DCPP). Ces deux types de liposomes permettent d'optimiser l'apport intracellulaire de N-butyl désoxynojirimycine (NB-DNJ) et d'augmenter ainsi l'activité in vivo de cet iminosucre de plusieurs ordres de grandeur, en offrant la possibilité d'une utilisation en combinaison avec d'autres agents thérapeutiques comme l'interféron et/ou la ribavirine. La libération optimisée de NB-DNJ directement dans l'ER peut aussi être appliquée pour le traitement d'autres virus, pour lesquels on sait que NB-DNJ est un antiviral efficace, comme le VIH.

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