Liposome with oligosaccharide on surface

Details Liposome with oligosaccharide on surface Liposome with oligosaccharide on surface

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 9/127 (2006.01) A61K 47/36 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2152917

A liposome as an adjuvant which is effective for somatic immunization and reduced in toxicity and antigenicity and can be administered to humans. The liposome comprises 2-11 saccharide residues and has on its surface an oligosaccharide which can combine with a lectin originating in an antigen- presenting cell, and a vaccine is prepared by enclosing an antigen in the liposome.

On décrit un liposome servant d'adjuvant efficace pour une immunisation somatique, à toxicité et antigénicité faibles et pouvant être administré à l'homme. Ce liposome comprend de 2 à 11 restes de saccharides et présente à sa surface un oligosaccharide pouvant se combiner avec une lectine provenant d'une cellule de présentation d'antigène. On décrit aussi un vaccin préparé en enfermant un antigène dans ce liposome.

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