Liposomes containing biologically active compounds

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/127 (2006.01) A61K 31/192 (2006.01) A61K 31/415 (2006.01) A61K 31/522 (2006.01)

Patent

CA 2489806

The present invention provides compositions of liposomes that contain a biologically active compound and methods of manufacture thereof. Invention methods offer the ability to manufacture liposome compositions containing NSAIDs and other biologically active compounds, and the ability to attain very high encapsulation efficiencies in uniform, stable liposomes. Compositions of liposomes containing anti-viral agents and anti-fungal agents are also provided. Invention liposome compositions are useful for the treatment of a variety of conditions, including, for example, pain and inflammation, bacterial infections and viral infections.

La présente invention concerne des compositions de liposomes contenant un composé biologiquement actif, ainsi que des procédés de fabrication de ces compositions. Les procédés selon l'invention permettent de fabriquer des compositions de liposomes contenant des anti-inflammatoires non stéroïdiens et d'autres composés biologiquement actifs, et d'atteindre un degré très élevé d'encapsulage dans des liposomes stables et uniformes. L'invention concerne également des compositions de liposomes contenant des agents antiviraux et antifongiques. Les compositions de liposomes selon l'invention servent au traitement de divers troubles tels que les douleurs, inflammations, infections bactériennes et infections virales.

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