Liposomes containing oligonucleotides

Details Liposomes containing oligonucleotides Liposomes containing oligonucleotides

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/127 (2006.01) A61K 31/711 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2484922

It is possible to radiosensitize tumor cells by administration of compositions containing the Human antisense c-raf-1 oligodeoxyribonucleotide (ODN/oligo) sequence: 5'- GTGCTCCATTGATGC-3' (seq. #1) or 5'-CCTGTATGTGCTCCATTGATGCAGC- 3' (seq. #2). These sequences wherein only the end bases are phosphorothioated is a preferred embodiment. Antisense sequences of up to 40 bases which contain this sequence may be used in accordance with the teachings of this disclosure. Compositions comprising a cationic liposome of dimethyldioctadecyl ammonium bromide, phosphatidylcholine and cholesterol may be used as a carrier system. The liposomes provide a new carrier system that is particularly useful for administration of sequences for therapy.

Affiliated with

Also associated with

Rating

Liposomes containing oligonucleotides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Liposomes containing oligonucleotides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Liposomes containing oligonucleotides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1988368