A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C12N 15/00 (2006.01) C12N 15/88 (2006.01) C12P 25/00 (2006.01)
Patent
CA 2271388
Cationic liposomes with entrapped polynucleotide in the intravesicular space are described. The liposomes include cationic components such as cationic lipids such as DOTAP. Preferably the method of forming liposomes uses the dehydration-rehydration method in the presence of the polynucleotide. The polynucleotide preferably operatively encodes an antigen capable of eliciting a desired immune response, that s, is a gene vaccine.
La présente invention se rapporte à des liposomes cationiques dans lesquels le polynucléotide est emprisonné à l'intérieur de l'espace intravésiculaire. Ces liposomes contiennent des composants cationiques tels que des lipides cationiques comme le DOTAP, par exemple. Pour former ces liposomes, on utilise de préférence un procédé de déshydratation-réhydratation en présence du polynucléotide. De préférence, ce polynucléotide code de façon fonctionnelle un antigène capable de déclencher une réaction immunitaire désirée, c'est-à-dire un vaccin génique.
Borden Ladner Gervais Llp
Lipoxen Technologies Limited
The School Of Pharmacy University Of London
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