Liposomes enclosing a radionuclide and a cytotoxic agent for...

Details Liposomes enclosing a radionuclide and a cytotoxic agent for... Liposomes enclosing a radionuclide and a cytotoxic agent for...

A - Human Necessities

61

K

A61K 51/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2583367

The present invention relates to cytotoxic agents comprising liposomes wherein the liposomes enclose a solution comprising at least one alpha emitting radionuclide and at least one other therapeutic agent, particularly a chemotherapeutic. The invention also provides methods for the formation of such cytotoxic agents, methods of therapy, especially cancer therapy employing the agents and methods for their use in the manufacture of medicaments.

L'invention concerne des agents cytotoxiques contenant des liposomes lesquels renferment un solution comprenant au moins un radionucléide émetteur de rayon alpha et au moins un autre agent thérapeutique, notamment chimiothérapeutique. L'invention concerne également des procédés de formation de ces agents cytotoxiques, des procédés de thérapie, notamment contre le cancer utilisant ces agents et des procédés d'utilisation de ceux-ci dans la fabrication de médicaments.

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