A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 31/282 (2006.01) A61K 33/24 (2006.01)
Patent
CA 2725529
The present invention provides liposomes that are useful for delivery of bioactive agents such as therapeutics. Among others, the liposomes of the invention are capable of delivering their payload at sites of increased secretory phospholipase A2 (sPLA2) activity, because phospholipase A2 (PLA2) will hydrolyse lipids of the liposome. Thus, the liposomes of the invention may e.g. be used in relation to cancer therapy. Another aspect of the invention is a liposomal formulation comprising the liposome of the invention. Still another aspect is a method of producing a liposomal formulation of the invention.
La présente invention concerne des liposomes utiles pour ladministration dagents bioactifs tels que des agents thérapeutiques. Les liposomes selon linvention sont capables, entre autres, dadministrer leur charge utile à des sites dactivité accrue de phospholipase A2 sécrétoire (sPLA2), étant donné que la phospholipase A2 va hydrolyser des lipides du liposome. Ainsi, les liposomes selon linvention peuvent, par exemple, être utilisés dans le contexte de la thérapie du cancer. Un autre aspect de linvention concerne une formulation liposomale comportant le liposome selon linvention. Selon un autre aspect, linvention concerne un procédé de production dune formulation liposomale selon linvention.
Henriksen Jonas Rosager
Joergensen Kent
Melander Fredrik
Petersen Sune Allan
Vikbjerg Anders Falk
Liplasome Pharma Aps
Macrae & Co.
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