Liposomes with an excess positive charge

Details Liposomes with an excess positive charge Liposomes with an excess positive charge

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 47/24 (2006.01)

Patent

CA 2081119

- 1 - A b s t r a c t New liposome structures are described which are characterized in that they contain at least 1 mol-% of a compound having the general formula (I) with an excess positive charge Image (I) in which R1 denotes alkoyl or alkyl each with 14 to 18 C atoms, oleoyl or oleyl, R2 denotes the group PNN Image R3 = -O-R1, -O-PNN, -O-Gly, NH3+, NH2CH3+, NH(CH3)2 or N(CH3)3+, R has one of the meanings stated for R1, R2 or R3 and n denotes a whole number from 0 to 3, and preferably denotes 0, provided that the molecule contains one of the said groups with a positive charge. - 2 - Due to their organ-specific characteristics the liposomes according to the present invention are especially suitable as pharmaceutical carriers in a pharmaceutical preparation for the treatment of diseases in the liver organ which contains one or several active substances which are active in the liver enclosed in the liposomes according to the present invention.

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