Liposomes with enhanced circulation time

A - Human Necessities – 61 – K

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167/163

A61K 9/127 (2006.01) B01J 13/02 (2006.01)

Patent

CA 1329769

-54- ABSTRACT A composition of liposomes which contain an entrapped pharmaceutical agent and are characterized by (a) liposome sizes predominantly between about 0.07 and 0.5 microns; (b) at least about 50 mole percent of a membrane-rigidifying lipid, such as sphingomyelin or neutral phospholipids with predominantly saturated acyl chains; and (c) between about 5-20 mole percent of a glycolipid selected from the group consisting of ganglioside GM1, saturated phosphatidylinositol, and galactocerebroside sulfate ester.

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