A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/232 (2006.01) A61P 27/02 (2006.01)
Patent
CA 2705465
Lipoxin A4 and its analogs have been discovered to promote the cell proliferation of cornea endothelial cells, and thus promote the proper functioning of the labile tissue layer of cornea endothelial cells. These lipoxin compounds can be administered alone or in combination with other known compounds as a solution that can be topically administered to decrease the swelling of the cornea or maintain the clarity of the cornea. Lipoxin A4 or its analogs can also be combined with other known nutritive compounds to form a solution for storage of a cornea prior to transplantation.
Selon l'invention, on a découvert que la lipoxine A4 et ses analogues favorisent la prolifération cellulaire de cellules endothéliales de cornée, permettant ainsi le fonctionnement correct de la couche de tissu labile de cellules endothéliales de la cornée. Ces composés de lipoxine peuvent être administrés individuellement ou en combinaison avec d'autres composés connus sous forme d'une solution qui peut être administrée par voie topique pour diminuer le gonflement de la cornée ou conserver la clarté de la cornée. La lipoxine A4 ou ses analogues peuvent également être combinés à d'autres composés nutritifs connus pour former une solution pour un stockage dans une cornée avant transplantation.
Bazan Haydee E. P.
Bazan Nicolas G.
He Jiu-Cheng
Board Of Supervisors Of Louisiana State University And Agricultu
Mccarthy Tetrault Llp
LandOfFree
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