Lipoxygenase inhibiting compounds

Details Lipoxygenase inhibiting compounds Lipoxygenase inhibiting compounds

C - Chemistry, Metallurgy

07

C

167/207, 167/265

C07C 275/64 (2006.01) A61K 31/17 (2006.01) C07D 209/26 (2006.01) C07D 209/40 (2006.01)

Patent

CA 2005445

- 25 - Abstract Compounds of the formula: Image I wherein A is CH2; n is 0 or 1; R1 and R2 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, aralkyl and cycloalkyl; Z is the residue from a non-steroidal anti-inflammatory carboxylic acid compound; and M is a pharmaceutically acceptable cation or a metabolically cleavable group; and the pharmaceutically acceptable salts thereof; and a non toxic pharmaceutically acceptable carrier. These compounds are useful as inhibitors of 5-lipoxygenase.

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