C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/04 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) C07D 307/14 (2006.01) C07D 307/22 (2006.01) C07D 309/04 (2006.01) C07D 333/24 (2006.01) C07D 335/02 (2006.01) C07D 405/06 (2006.01)
Patent
CA 2101539
2101539 9213848 PCTABS00014 Certain novel hydroxamic acid and hydroxyurea derivatives having structure (I), wherein R1 is hydrogen, alkyl, alkenyl, amino or substituted amino, R4 is hydrogen, a pharmaceutically acceptable cation, aroyl or alkoyl, A is alkylene or alkenylene, X is oxygen or sulfur, each Y is hydrogen, halo, cyano, hydroxy, alkyl, alkoxy, alkylthio, alkenyl, alkoxyalkyl, cycloalkyl, aryl, aryloxy, arylalkyl, arylalkenyl, arylalkoxy or substituted aryl, Z is oxygen or sulfur, m is 0 or 1, n is 1 to 5 and p is 2 to 6 inhibit the enzyme lipoxygenase. These compounds, and the pharmaceutically acceptable salts thereof, are useful in the treatment or alleviation of inflammatory diseases, allergic conditions and cardiovascular diseases in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions.
Limited Pfizer
Smart & Biggar
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