B - Operations – Transporting – 01 – J
Patent
B - Operations, Transporting
01
J
252/23, 73/93
B01J 20/32 (2006.01) B01D 15/08 (2006.01)
Patent
CA 1316523
LIQUID CHROMATOGRAPHY DUAL ZONE PACKING MATERIALS AND METHOD FOR MAKING AND USING SAME Abstract Dual zone reverse phase packing materials for use in liquid chromatographic blood serum analysis are prepared by contacting a porous support, such as porous silica, with a fluorocarbon silane, such as a perfluorobutylsilyl compound, to form a lipophobic phase in the external zone of the porous support, and, then contacting the porous support with a lipophilic silane, such as an octadecylsilyl compound, to form a lipophilic partitioning phase in the internal zone of the porous support. Ketal blocked diol groups, which later may be hydrolyzed to diol groups are also attached to both zones of the packing material. The dual zone reverse phase packing materials display a reduced degree of serum protein adsorption in the external zone while drug substances are retained and separated by the lipophilic partitioning phase in the internal zone.
562329
Dow Corning Corporation
Gowling Lafleur Henderson Llp
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