A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 9/107 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01)
Patent
CA 2697756
A dermal external pharmaceutical composition that excels in feeling at application or after application and that by enhancing of the transdermal absorption of cyclosporine,exerts medicinal benefits at low concentration. There is provided a liquid crystal emulsion-type pharmaceutical composition comprising cyclosporine, a hydrophilic nonionic surfactant, a lipophilic nonionic surfactant, an oil, a fatty acid that is insoluble in the oil at room temperature, a solid fatty alcohol that is insoluble in the oil at room temperature and a water-soluble polyhydric alcohol that is immiscible with the oil at room temperature, and a method of treating cutaneous diseases with the use of the pharmaceutical composition.
L'invention porte sur une composition pharmaceutique externe dermique qui présente une excellente caractéristique en termes de sensation à l'application ou après l'application et qui, par l'amélioration de l'absorption transdermique de la cyclosporine, exerce des bénéfices médicaux à une concentration faible. L'invention propose une composition pharmaceutique de type émulsion de cristaux liquides comportant de la cyclosporine, un agent tensioactif non ionique hydrophile, un agent tensioactif non ionique lipophile, un contenu huileux, un acide gras insoluble dans le contenu huileux à la température ambiante, un alcool supérieur solide insoluble dans le contenu huileux à la température ambiante et un polyol soluble dans l'eau immiscible avec le contenu huileux à la température ambiante, et propose un procédé de traitement de maladies de la peau à l'aide de la composition pharmaceutique.
Akamatsu Ryo
Fujii Masahiro
Horisawa Eijiro
Sakaguchi Tomoki
G. Ronald Bell & Associates
Maruho Co. Ltd.
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