Liquid crystal forms of cyclosporin

Details Liquid crystal forms of cyclosporin Liquid crystal forms of cyclosporin

A - Human Necessities

61

K

A61K 38/13 (2006.01) A61K 9/16 (2006.01) A61K 9/00 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2321268

This invention relates to novel, liquid crystal forms of the cyclic peptide cyclosporin and to novel powder formulations of cyclosporin prepared using this novel liquid crystal form of the drug. Methods for preparing and using these formulations are also provided. In particular, the present invention relates to dispersible spray dried particles of cyclosporin suitable for pulmonary delivery.

L'invention porte sur une nouvelle forme du peptide cyclique cyclosporine, en cristaux liquides, et sur de nouvelles préparations pulvérulentes de ce médicament utilisant cette nouvelle forme. L'invention porte également sur des procédés d'obtention desdites préparations et en particulier sur des aérosols de particules séchées de cyclosporine pénétrant dans le poumon.

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