Liquid formulation for deferiprone with palatable taste

Details Liquid formulation for deferiprone with palatable taste Liquid formulation for deferiprone with palatable taste

A - Human Necessities

61

K

A61K 31/4422 (2006.01) A61K 9/08 (2006.01) A61K 47/38 (2006.01) A61P 39/04 (2006.01)

Patent

CA 2722393

An oral pharmaceutical liquid formulation comprising deferiprone and a taste masking composition, said taste masking composition comprising an effective amount of a sweetener (such as sucralose) per litre of liquid composition, an effec-tive amount of a thickening and suspension aid, (for example hydroxyethylcellulose), per litre of liquid composition, an effective amount of a humectant (such as glycerin) per litre of liquid composition, and an effective amount of at least one flavoring agent, wherein a final form of said taste-masked pharmaceutical has a substantially non-bitter and palatable taste.

La présente invention porte sur une formulation pharmaceutique liquide orale à base de défériprone et d'une composition de masquage de goût, ladite composition de masquage de goût contenant une quantité efficace d'un édulcorant (tel que le sucralose) par litre de composition liquide, une quantité efficace d'un agent favorisant l'épaississement et la suspension (par exemple l'hydroxyéthylcellulose) par litre de composition liquide, une quantité efficace d'un humidifiant (tel que la glycérine) par litre de composition liquide, et une quantité efficace d'au moins un agent aromatisant. La saveur d'une forme finale de ladite formulation pharmaceutique à goût masqué est sensiblement non amère et agréable.

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