Liquid formulations of dihydropyridines, a process for their...

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A61K 31/455 (2006.01) A61K 31/44 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/26 (2006.01)

Patent

CA 1212326

ABSTRACT A rapidly absorbable liquid formulation of a dihydropyridine comprising, by weight, about 0.5 to 10 parts of a dihydropyridine of the formula Image in which R1 is C1-C4-alkyl, optionally substituted by C2-C3-alkoxy, R2 is C1-C10-alkyl, optionally substituted by C1-C3-alkoxy, trifluoromethyl or N-methyl-N-benzylamino, R3 is C1-C4-alkyl, cyano or hydroxymethyl, and X is 2- or 3-nitro, 2,3-dichloro or 2,3- =N-O-N=, 20 to 60 parts of a solubilizing agent and 80 to 40 parts of a diluent.

448601

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