A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/20 (2006.01) A61K 47/22 (2006.01)
Patent
CA 2197432
Immunoglobulin preparations, particularly liquid preparations of immunoglobulin G for intravenous infusion, are stabilized against dimer formation by the addition of one or more amphiphilic stabilizers. Preferred amphiphilic stabilizers are nicotinic acid derivatives, particularly nicotinamide, and naturally-occuring .alpha.-amino acids having a lipophilic side chain, for example phenylalanine, proline, leucine and isoleucine.
L'invention se rapporte à des préparations d'immunoglobulines, notamment à des préparations liquides d'immunoglobuline G utilisées dans les injections intraveineuses, lesquelles sont stabilisées, pour ne pas former de dimères, par addition d'au moins un stabilisant amphiphile. Les stabilisants amphiphiles préférés sont des dérivés d'acide nicotinique, notamment le nicotinamide, et d'acides alpha -amino d'origine naturelle à chaîne latérale lipophile, tels que la phénylalanine, la proline, la leucine et l'isoleucine.
Bruegger Rene
Gennari Katharina
Hodler Gerhard
Wuest Bernard
Csl Behring Ag
Kirby Eades Gale Baker
Red Cross Foundation Central Laboratory Blood Transfusion Servic
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