Liquid matrix transforming its phase in living body and oral...

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/36 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 31/43 (2006.01) A61K 31/496 (2006.01) A61K 31/545 (2006.01) A61K 31/65 (2006.01) A61K 31/7048 (2006.01) A61K 47/02 (2006.01) A61K 47/04 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2477964

It is intended to provide a liquid matrix for medicinal use in which a drug can be easily solubilized, dispersed or suspended and which can be easily swallowed because of being a liquid, has favorable working properties in sterilization and so on and a high stability, also exhibits an effect of masking bitterness, and gels in vivo so as to control the release speed, and liquid oral preparations using the same. Namely, a liquid matrix which is a liquid auxiliary facilitating the swallowing of a drug, characterized by containing a water-soluble polymer gelling under acidic conditions and the break stress of the gel being about 3.0x103 N/m2 or more. Liquid oral preparations having favorable slow release properties even though being a liquid.

La présente invention concerne une matrice liquide à usage médical dans laquelle un médicament peut facilement se solubiliser, se disperser ou rester en suspension. Cette matrice s'avale facilement car elle est liquide. Elle présente des propriétés de traitement favorables en stérilisation notamment, et un degré élevé de stabilité. Elle fait preuve d'un effet de masquage de l'amertume. En outre, elle prend en gel in vivo de façon à contrôler la vitesse de libération. L'invention concerne également des préparations liquides orales à base des mêmes. L'invention concerne plus particulièrement une matrice liquide qui est un auxiliaire liquide facilitant l'absorption d'un médicament, se caractérise en ce qu'elle contient un polymère hydrosoluble se prenant en gel dans un environnement acide, la contrainte de rupture du gel étant d'au moins environ 3,0 x 10?3¿ N/m?2¿. L'invention concerne enfin des préparations liquides orales présentant des propriétés favorables de libération lente, bien qu'étant un liquide.

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