Liquid pharmaceutical compositions comprising thyroid hormones

Details Liquid pharmaceutical compositions comprising thyroid hormones Liquid pharmaceutical compositions comprising thyroid hormones

A - Human Necessities

61

K

A61K 31/195 (2006.01) A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 47/10 (2006.01)

Patent

CA 2182037

There is disclosed a liquid pharmaceutical composition comprising a therapeutic agent which comprises: one or more thyroid hormone or hormones; from about 40 % to about 96 % ethanol by volume; a pH adjusting agent so that the measured pH of the composition is from about 9 to about 12; and from about 4 % to about 50 % water by volume; which has utility in the treatment of disorders associated with an impairment of the thyroid hormone function in animals including human beings. The liquid composition may be delivered by a metered dosage delivery system such as an aerosol or pump-action spray.

L'invention se rapporte à une composition pharmaceutique liquide comprenant un agent thérapeutique qui contient: une ou plusieurs hormones thyroïdiennes, d'environ 40 % à environ 96 % en volume d'éthanol; un agent ajustant le niveau de pH de façon à ce que le pH mesuré de la composition soit d'environ 9 à environ 12; et d'environ 4 % à environ 50 % en volume d'eau. Cette composition est utilisée dans le traitement de troubles associés à l'insuffisance de l'hormone thyroïdienne chez les animaux, y compris chez les êtres humains. La composition liquide peut être administrée par un système doseur tel qu'un aérosol ou un vaporisateur actionné par un pompe.

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