Liquid pharmaceutical formulations of acetaminophen and an...

Details Liquid pharmaceutical formulations of acetaminophen and an... Liquid pharmaceutical formulations of acetaminophen and an...

A - Human Necessities

61

K

A61K 9/48 (2006.01) A61K 9/64 (2006.01) A61K 31/16 (2006.01)

Patent

CA 2466770

The invention herein provides for an oral pharmaceutical composition adapted for use in capsular dosage forms comprising acetaminophen and a lactate salt alone or in combination with an acetate salt. Compositions of the invention exhibit improved solubility characteristics of the active ingredient per given fill volume, thereby permitting the use of smaller capsule sizes to deliver a given effective dose of the active ingredient. Compositions of the invention also exhibit improved clarity per concentration of active ingredient. The invention also provides for a capsular dosage form containing the composition.

L'invention concerne une composition pharmaceutique à administrer par voie orale, conçue pour être utilisée sous forme de capsule dosée, comprenant de l'acétaminophène et un sel de lactate seul ou en combinaison avec un sel d'acétate. La solubilité du principe actif par volume de remplissage donné des compositions selon l'invention est améliorée, ce qui permet ainsi l'utilisation de capsules de plus petite taille pour administrer une dose efficace donnée dudit principe actif. Les compositions de l'invention présentent également une limpidité améliorée par concentration de principe actif. L'invention concerne en outre une forme de dosage en capsule contenant ladite composition.

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