Liquid phase synthesis of peptides and peptide derivatives

Details Liquid phase synthesis of peptides and peptide derivatives Liquid phase synthesis of peptides and peptide derivatives

C - Chemistry, Metallurgy

07

K

C07K 5/103 (2006.01) C07K 1/02 (2006.01) C07K 1/06 (2006.01) C07K 1/10 (2006.01)

Patent

CA 2115668

2115668 9325571 PCTABS00028 A liquid phase peptide synthetic method which uses (1) Fmoc as the protecting group for the non-side chain amino functionality, (2) ammonia, a primary or secondary amine to remove the Fmoc protecting group, and (3) substituted carbodiimide as the coupling agent for the C to N synthesis of peptides or peptide derivatives in a proper organic solvent.

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