Liquid stable composition of oxazaphosphorine with mesna

Details Liquid stable composition of oxazaphosphorine with mesna Liquid stable composition of oxazaphosphorine with mesna

A - Human Necessities

61

K

A61K 31/675 (2006.01) A61K 31/185 (2006.01) A61K 31/724 (2006.01) A61K 47/40 (2006.01)

Patent

CA 2497898

A low toxicity, stable oxazaphosphorine containing compositions with mesna for parenteral administration has been described. The process essentially requires addition of an oxazaphosphorine antineoplastic to the aqueous solution of an etherified b-cyclodextrin followed by addition of mesna as such or as an aqueous solution containing optionally, an etherified b-cyclodextrin. Preferably, the oxazaphosphorine antineoplastic is Ifosfamide and the etherified b-cyclodextrin is 2-hydroxypropyl-b-cyclodextrin.

La présente invention concerne des compositions stables à faible toxicité qui contiennent de l'oxazaphosphorine et du mesna et qui sont destinées à être administrées par voie parentérale. Le processus implique principalement d'ajouter un antinéoplasique oxazaphosphorine à la solution aqueuse d'une b-cyclodextrine éthérifiée et d'ajouter ensuite du mesna en tant que tel ou sous forme d'une solution aqueuse contenant facultativement une b-cyclodextrine éthérifiée. De préférence, l'antinéoplasique oxazaphosphorine est l'Ifosfamide et la b-cyclodextrine éthérifiée est la 2-hydroxypropyl-b-cyclodextrine.

Affiliated with

Also associated with

Rating

Liquid stable composition of oxazaphosphorine with mesna does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Liquid stable composition of oxazaphosphorine with mesna, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Liquid stable composition of oxazaphosphorine with mesna will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1911097