Lisinopril

Details Lisinopril Lisinopril

C - Chemistry, Metallurgy

07

K

530/5.06, 167/10

C07K 5/06 (2006.01) A61K 37/02 (1985.01)

Patent

CA 1275350

A B S T R A C T The invention relates to new carboxyalkyl dipeptide derivatives of the formula: Image wherein R and R6 are the same or different and are hydroxy or loweralkoxy; R1 is a substituted lower alkyl wherein the substituent is phenyl or halophenyl; R2 and R7 are hydrogen, R3 is lower alkyl amino; R4 is lower alkyl; R5 is lower alkyl; R4 and R5 may be connected together to form an alkylene bridge of from 2 to 4 carbon atoms; and the pharmaceutically acceptable salts thereof. These compounds are useful as converting enzyme inhibitors and as antihypertensives.

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