Lisofylline analogs and methods for use

Details Lisofylline analogs and methods for use Lisofylline analogs and methods for use

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4196 (2006.01) A61K 31/502 (2006.01) A61K 31/53 (2006.01) A61K 31/538 (2006.01) A61P 3/10 (2006.01) C07D 237/32 (2006.01) C07D 237/34 (2006.01) C07D 249/12 (2006.01) C07D 265/36 (2006.01)

Patent

CA 2618970

The present invention provides analogs of formula (I) of a Lysofylline (LSF), and synthetic methods for the preparation of such analogs. The have the active side chain moiety (5-R-hydroxyhexyl) of LSF and can have greater potency and oral bioavailability than LSF. The compounds (II) are used to treat diabetes, inflammatory and autoimmune conditions. wherein R1 is hydrogen or a group having the formula -C(=O)R3, wherein R is lower alkyl, and R2 is selected from the group consisting of.

L'invention concerne des analogues d'une Lysofylline (LSF) et des procédés synthétiques de préparation de tels analogues. Ceux-ci possèdent la fraction de chaîne latérale active (5-R-hydroxyhexyl) de LSF et peuvent posséder une puissance et une biodisponibilité orale supérieures à la LSF.

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