A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/02 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C12N 1/21 (2006.01) C12N 15/00 (2006.01)
Patent
CA 2515369
The present invention provides Listeria that are attenuated for entry into non- phagocytic cells as well as a variety of methods of inducing immune responses involving administering compositions comprising the attenuated Listeria. Some of the attenuated Listeria are mutant Listeria that comprise at least one mutation in a gene encoding an invasin, such as an internalin. Some of the attenuated Listeria are further attenuated for cell-to-cell spread. Pharmaceutical compositions and vaccines useful in the methods of the invention are further provided. Methods of making and improving vaccines are also provided.
La présente invention concerne des <i>Listeria </i> qui sont atténuées en vue d'une entrée dans des cellules non phagocytaires ainsi qu'une variété de techniques qui permettant d'induire des réponses immunitaires consistant à administrer des compositions comprenant les <i>Listeria</i> atténuées. Certaines de ces <i>Listeria</i> atténuées sont des <i>Listeria</i> mutantes qui comprennent au moins une mutation dans un gène codant pour une invasine, telle qu'une internaline. Certaines de ces <i>Listeria</i> atténuées sont à nouveau atténuées en vue d'une propagation de cellule à cellule. C'est invention concerne aussi des compositions pharmaceutiques et des vaccins qui conviennent dans les techniques de l'invention ainsi que des techniques de fabrication et d'amélioration de vaccins.
Brockstedt Dirk G.
Cook David
Dubensky Thomas W. Jr.
Aduro Biotech
Borden Ladner Gervais Llp
Cerus Corporation
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